Health Conditions
Celiac Disease
Celiac Disease is an autoimmune disease affecting 1 in 133 people or 1% of the population. In Celiac Disease, the immune system reacts to gluten, sometimes causing damage in the small intestine.
Symptoms
Patients with celiac disease can experience:
Abdominal pain
Diarrhea
Weight loss
Bloating
Nausea
Vomiting
Constipation
Causes
The exact cause of celiac disease is unknown; however, genetics, specific gut bacteria, intestinal infections, and infant feeding practices may contribute to disease development. For individuals with Celiac Disease, the immune system becomes irritated in the presence of gluten and this irritation can damage the villi in the small intestine.
Treatment
The best current management for celiac disease is a lifelong gluten-free diet. Even small traces of gluten can cause inflammation of the small intestine. Patients can work with a dietician to help create a gluten-free diet that works best for them.
Microbiota Therapy Research
Researchers at the University of Minnesota are analyzing the microbiome of patients with celiac disease.
The Gut Microbiome and T Cells in Celiac Disease
Trial Location: University of Minnesota – Minneapolis, MN
Trial Status: Underway
Trial Summary:
In celiac disease, T cells that recognize proteins from wheat, barley, and rye (gluten) cause inflammation in the gut. However, it is unclear what triggers this inflammation. In this study, researchers at the University of Minnesota are trying to understand if differences in intestinal bacteria correspond to differences in these T cells in healthy individuals compared to those with celiac disease. This is a non-interventional study where we are collecting duodenal fluid (aspirates), duodenal biopsies, blood, and fecal samples to track these differences.
For more information, visit: https://med.umn.edu/divisions/gastroenterology-hepatology-and-nutrition/clinical-studies
Research Partner Perspectives
2026 Webinar: Dr. Weingarden
Research Alerts